import tkinter as tk
from tkinterdnd2 import DND_FILES, TkinterDnD

window = TkinterDnD.Tk()

main_frame = tk.Frame(window, padx=50, pady=20)
main_frame.pack(fill=tk.BOTH, expand=True)

listbox = tk.Listbox(main_frame)
listbox.drop_target_register(DND_FILES)
listbox.dnd_bind('<<Drop>>', lambda x: listbox.insert(tk.END, x.data))
listbox.pack(fill=tk.BOTH, expand=True)

button = tk.Button(main_frame, text='Button')
button.pack(fill=tk.BOTH, expand=True)

window.mainloop()